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MGP000688

UniProt Annotations

Entry Information
Gene NameC-reactive protein, pentraxin-related
Protein EntryCRP_HUMAN
UniProt IDP02741
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P02741-1; Sequence=Displayed; Name=2; IsoId=P02741-2; Sequence=VSP_004656; Note=No experimental confirmation available.;
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
FunctionDisplays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
InductionThe concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.
InteractionP31995:FCGR2C; NbExp=2; IntAct=EBI-1395983, EBI-1396036;
Mass SpectrometryMass=22930; Method=MALDI; Range=19-223; Evidence={ECO:0000269|Ref.15};
Mass SpectrometryMass=23028; Method=MALDI; Range=19-224; Evidence={ECO:0000269|Ref.15};
MiscellaneousThis protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
SimilarityBelongs to the pentaxin family. {ECO:0000305}.
SimilarityContains 1 pentaxin domain. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1. {ECO:0000269|PubMed:21037097}.
Tissue SpecificityFound in plasma.
Web ResourceName=Protein Spotlight; Note=No more Christmas pudding? - Issue 30 of January 2003; URL="http://web.expasy.org/spotlight/back_issues/030";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/crp/";
Web ResourceName=Wikipedia; Note=C-reactive protein entry; URL="http://en.wikipedia.org/wiki/C-reactive_protein";
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