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MGP000694

Record overview

MGPD IDMGP000694
Gene ID1437
SpeciesHomo sapiens (Human)
Gene Namecolony stimulating factor 2 (granulocyte-macrophage)
Gene Symbol CSF2
SynonymsGMCSF;
Alternate namesgranulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim;
Chromosome5
Map Location5q31.1
SummaryThe protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CSF2

Proteins

granulocyte-macrophage colony-stimulating factor precursor
Refseq ID:NP_000749
Protein GI:27437030
UniProt ID:P04141
mRNA ID:NM_000758
Length:144
RefSeq Status:
MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASH
YKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1835
peptide sequence: 
MWLQSLLLLGTVACSIS

mat_peptide: 18..144
product: Granulocyte-macrophage colony-stimulating factor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P04141.1)
calculated_mol_wt: 14478
peptide sequence: 
APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQI
ITFESFKENLKDFLLVIPFDCWEPVQE
 
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