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MGP000694

UniProt Annotations

Entry Information
Gene Namecolony stimulating factor 2 (granulocyte-macrophage)
Protein EntryCSF2_HUMAN
UniProt IDP04141
SpeciesHuman
Comments
Comment typeDescription
FunctionCytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
InteractionP32927:CSF2RB; NbExp=2; IntAct=EBI-1809826, EBI-1809771;
PharmaceuticalAvailable under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia.
PolymorphismVariant Ile-117 may be a risk factor for atopic asthma.
SimilarityBelongs to the GM-CSF family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitMonomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. {ECO:0000269|PubMed:18692472}.
Web ResourceName=Leukine; Note=Clinical information on Leukine; URL="http://www.leukine.com/healthcare.aspx";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/csf2/";
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