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MGP000716

Record overview

MGPD IDMGP000716
Gene ID1488
SpeciesHomo sapiens (Human)
Gene NameC-terminal binding protein 2
Gene Symbol CTBP2
Alternate namesC-terminal-binding protein 2; ribeye;
Chromosome10
Map Location10q26.13
SummaryThis gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
OrthologsView orthologs and multiple alignments for CTBP2

Proteins

C-terminal-binding protein 2 isoform 1
Refseq ID:NP_001077383
Protein GI:145580578
UniProt ID:P56545
mRNA ID:NM_001083914
Length:445
RefSeq Status:
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRV
IVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAK
AFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHES
EPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLP
AAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ
 
C-terminal-binding protein 2 isoform 1
Refseq ID:NP_001277144
Protein GI:589269185
UniProt ID:P56545
mRNA ID:NM_001290215
Length:445
RefSeq Status:
Protein sequence is identical to GI:145580578 (mRNA isoform)
 
C-terminal-binding protein 2 isoform 1
Refseq ID:NP_001277143
Protein GI:589269183
UniProt ID:P56545
mRNA ID:NM_001290214
Length:445
RefSeq Status:
Protein sequence is identical to GI:145580578 (mRNA isoform)
 
C-terminal-binding protein 2 isoform 1
Refseq ID:NP_001320
Protein GI:4557499
UniProt ID:P56545
mRNA ID:NM_001329
Length:445
RefSeq Status:
Protein sequence is identical to GI:145580578 (mRNA isoform)
 
C-terminal-binding protein 2 isoform 2
Refseq ID:NP_073713
Protein GI:145580575
UniProt ID:P56545
mRNA ID:NM_022802
Length:985
RefSeq Status:
MPVPSRHINIGRSQSWDAAGWYEGPWENAESLRPLGRRSSLTYGTAEGTWFEPNHRPQDAALPVAAEPYLYREAVYNSVAARKGSTPDFTFYDSRQAVMS
GRSPLLPREYYSDPSGAARVPKEPPLYRDPGVSRPVPSYGVLGSRTSWDPMQGRSPALQDAGHLYRDPGGKMIPQGRQTQSRAASPGRYGREQPDTRYGA
EVPAYPLSQVFSDISERPIDPAPARQVAPTCLVVDPSSAAAPEGSTGVAPGALNRGYGPARESIPSKMAYETYEADLSTFQGPGGKRTVLPEFLAFLRAE
GLAEATLGALLQQGFDSPAVLATLEDADIKSVAPNLGQARVLSRLANSCRTEMQLRRQDRGGPLPRARSSSFSHRSELLHGDLASLGAAAPLQTASPRAG
DPARRPSSAPSQHLLETAATYSAPGVGTHAPHFPSNSGYSSPTPCALTARLSPTYPLQAGVALTNPGPSNPLHPGPRTAYSTAYTVPMELLKRERNVAAS
PLPSPHGSPQVLRKPGAPLGPSTLPPASQSLHTPHSPYQKVARRTGAPIIVSTMLAPEPSIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFC
DAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGT
RVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQ
MRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKE
FFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ
 
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