MGP Database

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MGP000716

Ontology/Pathway Information

Entrez Gene ID1488
Gene NameC-terminal binding protein 2
Gene Symbol CTBP2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0005634 IDA:UniProtKBCnucleus
GO:0045202 IEA:UniProtKB-SubCellCsynapse
GO:0017053 ISS:UniProtKBCtranscriptional repressor complex
GO:0051287 IEA:InterProFNAD binding
GO:0016616 IEA:InterProFoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0003714 IEA:EnsemblFtranscription corepressor activity
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0045892 ISS:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0048386 IMP:MGIPpositive regulation of retinoic acid receptor signaling pathway
GO:0045944 IMP:MGIPpositive regulation of transcription from RNA polymerase II promoter
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0019079 TAS:ProtIncPviral genome replication
GO:0050872 ISS:UniProtKBPwhite fat cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_264567repression of WNT target genes
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
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