MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000716

UniProt Annotations

Entry Information
Gene NameC-terminal binding protein 2
Protein EntryCTBP2_HUMAN
UniProt IDP56545
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P56545-1; Sequence=Displayed; Name=2; Synonyms=Ribeye; IsoId=P56545-2; Sequence=VSP_027615; Note=Ref.2 (AAG45951) sequence is in conflict in positions: 455:Y->H, 539:Q->E. {ECO:0000305};
FunctionCorepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.
FunctionIsoform 2 probably acts as a scaffold for specialized synapses.
InteractionP20749:BCL3; NbExp=2; IntAct=EBI-741533, EBI-958997; P51946:CCNH; NbExp=5; IntAct=EBI-741533, EBI-741406; Q14526:HIC1; NbExp=2; IntAct=EBI-741533, EBI-2507362; O75807:PPP1R15A; NbExp=2; IntAct=EBI-741533, EBI-714746; Q92786:PROX1; NbExp=2; IntAct=EBI-741533, EBI-3912635; Q9UN79:SOX13; NbExp=2; IntAct=EBI-741533, EBI-3928516; A2APF7:Zbp1 (xeno); NbExp=2; IntAct=EBI-741533, EBI-6115394;
SimilarityBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}. Cell junction, synapse {ECO:0000250}.
SubunitInteracts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. {ECO:0000250, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:16702210, ECO:0000269|Ref.16}.
Tissue SpecificityUbiquitous. Highest levels in heart, skeletal muscle, and pancreas.
  logo