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MGP000717

Record overview

MGPD IDMGP000717
Gene ID1490
SpeciesHomo sapiens (Human)
Gene Nameconnective tissue growth factor
Gene Symbol CTGF
SynonymsCCN2; NOV2; HCS24; IGFBP8;
Alternate namesconnective tissue growth factor; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8;
Chromosome6
Map Location6q23.1
SummaryThe protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
OrthologsView orthologs and multiple alignments for CTGF

Proteins

connective tissue growth factor precursor
Refseq ID:NP_001892
Protein GI:4503123
UniProt ID:P29279
mRNA ID:NM_001901
Length:349
RefSeq Status:
MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDG
APCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCL
VQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT
LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
 
sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2617
peptide sequence: 
MTAASMGPVRVAFVVLLALCSRPAVG
 
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