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MGP000717

UniProt Annotations

Entry Information

Gene Name	connective tissue growth factor
Protein Entry	CTGF_HUMAN
UniProt ID	P29279
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P29279-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P29279-2; Sequence=VSP_002460; Note=No experimental confirmation available.;
Function	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. {ECO:0000269\|PubMed:10614647, ECO:0000269\|PubMed:12553878}.
Interaction	P02751:FN1; NbExp=5; IntAct=EBI-2835375, EBI-1220319;
Similarity	Belongs to the CCN family. {ECO:0000305}.
Similarity	Contains 1 CTCK (C-terminal cystine knot-like) domain. {ECO:0000255\|PROSITE-ProRule:PRU00039}.
Similarity	Contains 1 IGFBP N-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00653}.
Similarity	Contains 1 TSP type-1 domain. {ECO:0000255\|PROSITE- ProRule:PRU00210}.
Similarity	Contains 1 VWFC domain. {ECO:0000255\|PROSITE- ProRule:PRU00220}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted {ECO:0000250}.
Subunit	Monomer.
Tissue Specificity	Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. {ECO:0000269\|PubMed:1756408}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTGFID40192ch6q23.html";