MGP Database

MGP000717

Ontology/Pathway Information

Entrez Gene ID	1490
Gene Name	connective tissue growth factor
Gene Symbol	CTGF
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005938	IEA:Ensembl	C	cell cortex
GO:0005801	IEA:Ensembl	C	cis-Golgi network
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0005794	IDA:HPA	C	Golgi apparatus
GO:0043231	IDA:HPA	C	intracellular membrane-bounded organelle
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005886	TAS:ProtInc	C	plasma membrane
GO:0005578	TAS:ProtInc	C	proteinaceous extracellular matrix
GO:0008201	IEA:UniProtKB-KW	F	heparin binding
GO:0005520	TAS:ProtInc	F	insulin-like growth factor binding
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0001502	IEA:Ensembl	P	cartilage condensation
GO:0030154	IEA:Ensembl	P	cell differentiation
GO:0007160	IEA:Ensembl	P	cell-matrix adhesion
GO:0016477	IEA:Ensembl	P	cell migration
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0035988	IEA:Ensembl	P	chondrocyte proliferation
GO:0060401	IEA:Ensembl	P	cytosolic calcium ion transport
GO:0071897	IEA:UniProtKB-KW	P	DNA biosynthetic process
GO:0008544	TAS:ProtInc	P	epidermis development
GO:0070278	IEA:Ensembl	P	extracellular matrix constituent secretion
GO:0008543	IEA:Ensembl	P	fibroblast growth factor receptor signaling pathway
GO:0010467	TAS:Reactome	P	gene expression
GO:0007229	IEA:Ensembl	P	integrin-mediated signaling pathway
GO:0035556	IEA:Ensembl	P	intracellular signal transduction
GO:0030324	IEA:Ensembl	P	lung development
GO:0060548	IEA:Ensembl	P	negative regulation of cell death
GO:0010629	IEA:Ensembl	P	negative regulation of gene expression
GO:0010260	IEA:Ensembl	P	organ senescence
GO:0001503	IEA:Ensembl	P	ossification
GO:0060452	IEA:Ensembl	P	positive regulation of cardiac muscle contraction
GO:0050867	IEA:Ensembl	P	positive regulation of cell activation
GO:0045597	IDA:BHF-UCL	P	positive regulation of cell differentiation
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0032967	IEA:Ensembl	P	positive regulation of collagen biosynthetic process
GO:0043280	IEA:Ensembl	P	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070374	IDA:BHF-UCL	P	positive regulation of ERK1 and ERK2 cascade
GO:0070318	IEA:Ensembl	P	positive regulation of G0 to G1 transition
GO:0046330	IDA:BHF-UCL	P	positive regulation of JNK cascade
GO:0001934	IEA:Ensembl	P	positive regulation of protein phosphorylation
GO:0051496	IDA:BHF-UCL	P	positive regulation of stress fiber assembly
GO:0072593	IEA:Ensembl	P	reactive oxygen species metabolic process
GO:0001558	IEA:InterPro	P	regulation of cell growth
GO:0032330	IEA:Ensembl	P	regulation of chondrocyte differentiation
GO:0043200	IEA:Ensembl	P	response to amino acid
GO:0034059	IEA:Ensembl	P	response to anoxia
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0070542	IEA:Ensembl	P	response to fatty acid
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0051385	IEA:Ensembl	P	response to mineralocorticoid
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0009611	TAS:ProtInc	P	response to wounding
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0001894	IEA:Ensembl	P	tissue homeostasis
GO:0006367	TAS:Reactome	P	transcription initiation from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_22279	Fatty acid, triacylglycerol, and ketone body metabolism
REACT_71	Gene Expression
REACT_12627	Generic Transcription Pathway
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_116145	PPARA activates gene expression
REACT_19241	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_118713	YAP1- and WWTR1 (TAZ)-stimulated gene expression