MGP Database

MGP000726

Record overview

MGPD IDMGP000726
Gene ID1508
SpeciesHomo sapiens (Human)
Gene Namecathepsin B
Gene Symbol CTSB
SynonymsAPPS; CPSB;
Alternate namescathepsin B; APP secretase; amyloid precursor protein secretase; cathepsin B1; cysteine protease;
Chromosome8
Map Location8p22
EC Number3.4.22.1
SummaryThe protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CTSB

Proteins

cathepsin B preproprotein
Refseq ID:NP_680090
Protein GI:22538431
UniProt ID:P07858
mRNA ID:NM_147780
Length:339
RefSeq Status:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIR
DQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTG
EGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MWQLWASLCCLLVLANA

mat_peptide: 80..126
product: cathepsin B light chain
calculated_mol_wt: 5209
peptide sequence: 
LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN

mat_peptide: 129..333
product: cathepsin B heavy chain
calculated_mol_wt: 22416
peptide sequence: 
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD
 
cathepsin B preproprotein
Refseq ID:NP_680092
Protein GI:22538435
UniProt ID:P07858
mRNA ID:NM_147782
Length:339
RefSeq Status:
Protein sequence is identical to GI:22538431 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MWQLWASLCCLLVLANA

mat_peptide: 80..126
product: cathepsin B light chain
calculated_mol_wt: 5209
peptide sequence: 
LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN

mat_peptide: 129..333
product: cathepsin B heavy chain
calculated_mol_wt: 22416
peptide sequence: 
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD
 
cathepsin B preproprotein
Refseq ID:NP_001899
Protein GI:4503139
UniProt ID:P07858
mRNA ID:NM_001908
Length:339
RefSeq Status:
Protein sequence is identical to GI:22538431 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MWQLWASLCCLLVLANA

mat_peptide: 80..126
product: cathepsin B light chain
calculated_mol_wt: 5209
peptide sequence: 
LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN

mat_peptide: 129..333
product: cathepsin B heavy chain
calculated_mol_wt: 22416
peptide sequence: 
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD
 
cathepsin B preproprotein
Refseq ID:NP_680093
Protein GI:22538437
UniProt ID:P07858
mRNA ID:NM_147783
Length:339
RefSeq Status:
Protein sequence is identical to GI:22538431 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MWQLWASLCCLLVLANA

mat_peptide: 80..126
product: cathepsin B light chain
calculated_mol_wt: 5209
peptide sequence: 
LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN

mat_peptide: 129..333
product: cathepsin B heavy chain
calculated_mol_wt: 22416
peptide sequence: 
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD
 
cathepsin B preproprotein
Refseq ID:NP_680091
Protein GI:22538433
UniProt ID:P07858
mRNA ID:NM_147781
Length:339
RefSeq Status:
Protein sequence is identical to GI:22538431 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MWQLWASLCCLLVLANA

mat_peptide: 80..126
product: cathepsin B light chain
calculated_mol_wt: 5209
peptide sequence: 
LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN

mat_peptide: 129..333
product: cathepsin B heavy chain
calculated_mol_wt: 22416
peptide sequence: 
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1935 peptide sequence: MWQLWASLCCLLVLANA mat_peptide: 80..126 product: cathepsin B light chain calculated_mol_wt: 5209 peptide sequence: LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN mat_peptide: 129..333 product: cathepsin B heavy chain calculated_mol_wt: 22416 peptide sequence: VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD
 
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