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MGP000726

UniProt Annotations

Entry Information

Gene Name	cathepsin B
Protein Entry	CATB_HUMAN
UniProt ID	P07858
Species	Human

Comments

Comment type	Description
Catalytic Activity	Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-\|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
Function	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Interaction	Q6UY14:ADAMTSL4; NbExp=3; IntAct=EBI-715062, EBI-742002; P02760:AMBP; NbExp=4; IntAct=EBI-715062, EBI-2115136; P40692:MLH1; NbExp=7; IntAct=EBI-715062, EBI-744248; Q9NYA1:SPHK1; NbExp=4; IntAct=EBI-715062, EBI-985303;
Similarity	Belongs to the peptidase C1 family. {ECO:0000255\|PROSITE-ProRule:PRU10088, ECO:0000255\|PROSITE- ProRule:PRU10089, ECO:0000255\|PROSITE-ProRule:PRU10090}.
Subcellular Location	Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Subunit	Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. {ECO:0000269\|PubMed:18718938}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSBID40202ch8p23.html";