MGP Database

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MGP000753

Ontology/Pathway Information

Entrez Gene ID1557
Gene Namecytochrome P450, family 2, subfamily C, polypeptide 19
Gene Symbol CYP2C19
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IBA:GO_CentralCcytoplasm
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0043231 TAS:ProtIncCintracellular membrane-bounded organelle
GO:0008392 IBA:GO_CentralFarachidonic acid epoxygenase activity
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 IDA:BHF-UCLFmonooxygenase activity
GO:0016491 IDA:BHF-UCLFoxidoreductase activity
GO:0016712 IBA:GO_CentralFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:ProtIncFoxygen binding
GO:0052741 IEA:UniProtKB-ECF(R)-limonene 6-monooxygenase activity
GO:0018675 IEA:UniProtKB-ECF(S)-limonene 6-monooxygenase activity
GO:0018676 IEA:UniProtKB-ECF(S)-limonene 7-monooxygenase activity
GO:0008395 IMP:BHF-UCLFsteroid hydroxylase activity
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0017144 IDA:BHF-UCLPdrug metabolic process
GO:0019373 IBA:GO_CentralPepoxygenase P450 pathway
GO:0042738 IDA:BHF-UCLPexogenous drug catabolic process
GO:0046483 IDA:BHF-UCLPheterocycle metabolic process
GO:0016098 IDA:BHF-UCLPmonoterpenoid metabolic process
GO:0097267 TAS:ReactomePomega-hydroxylase P450 pathway
GO:0055114 IDA:BHF-UCLPoxidation-reduction process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 IMP:BHF-UCLPsteroid metabolic process
GO:0006805 IBA:GO_CentralPxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_13433Biological oxidations
REACT_13797CYP2E1 reactions
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_13705Phase 1 - Functionalization of compounds
REACT_150134Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
REACT_150417Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
REACT_13543Xenobiotics
SMP Pathway Links
SMP IDDescription
SMP00634Carbamazepine Metabolism Pathway
SMP00424Citalopram Action Pathway
SMP00627Citalopram Metabolism Pathway
SMP00639Clomipramine Metabolism Pathway
SMP00260Clopidogrel Action Pathway
SMP00610Clopidogrel Metabolism Pathway
SMP00447Cyclophosphamide Action Pathway
SMP00604Cyclophosphamide Metabolism Pathway
SMP00641Doxepin Metabolism Pathway
SMP00426Fluoxetine Action Pathway
SMP00646Fluoxetine Metabolism Pathway
SMP00086Ibuprofen Action Pathway
SMP00590Ibuprofen Metabolism Pathway
SMP00422Imipramine Action Pathway
SMP00625Imipramine Metabolism Pathway
SMP00408Methadone Action Pathway
SMP00624Methadone Metabolism Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00636Venlafaxine Metabolism Pathway
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