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MGP000834

Record overview

MGPD IDMGP000834
Gene ID1734
SpeciesHomo sapiens (Human)
Gene Namedeiodinase, iodothyronine, type II
Gene Symbol DIO2
SynonymsD2; 5DII; SelY; DIOII; TXDI2;
Alternate namestype II iodothyronine deiodinase; type 2 DI; deiodinase-2; deiodonase-2; type-II 5'deiodinase; type-II 5'-deiodinase; thyroxine deiodinase, type II; type 2 iodothyronine deiodinase;
Chromosome14
Map Location14q24.2-q24.3
EC Number1.97.1.10
SummaryThe protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DIO2

Proteins

type II iodothyronine deiodinase isoform a
Refseq ID:NP_054644
Protein GI:7549803
UniProt ID:Q92813
mRNA ID:NM_013989
Length:273
RefSeq Status:
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGN
GTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLE
RFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
 
type II iodothyronine deiodinase isoform a
Refseq ID:NP_000784
Protein GI:7549805
UniProt ID:Q92813
mRNA ID:NM_000793
Length:273
RefSeq Status:
Protein sequence is identical to GI:7549803 (mRNA isoform)
 
type II iodothyronine deiodinase isoform b
Refseq ID:NP_001007024
Protein GI:55749998
UniProt ID:Q92813
mRNA ID:NM_001007023
Length:309
RefSeq Status:
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQLNCPPSGFSKDGHILULVYEAYKSRL
LVYSHLDLWMVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEA
HPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSK
RUKKTRLAG
 
type II iodothyronine deiodinase isoform c
Refseq ID:NP_001229431
Protein GI:335353782
UniProt ID:Q92813
mRNA ID:NM_001242502
Length:146
RefSeq Status:
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQLNCPPSGFSKDGHILULVYEAYKSRL
LVYSHLDLWMTDSVVLTLNFPRQISLCFGKNSAAELYIVSKKEKVP
 
type II iodothyronine deiodinase isoform d
Refseq ID:NP_001229432
Protein GI:335353784
UniProt ID:Q92813
mRNA ID:NM_001242503
Length:110
RefSeq Status:
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQTDSVVLTLNFPRQISLCFGKNSAAEL
YIVSKKEKVP
 
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