MGP Database

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MGP000834

UniProt Annotations

Entry Information
Gene Namedeiodinase, iodothyronine, type II
Protein EntryIOD2_HUMAN
UniProt IDQ92813
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=hDII-a; IsoId=Q92813-1; Sequence=Displayed; Name=2; Synonyms=hDII-b; IsoId=Q92813-2; Sequence=VSP_026154; Note=Has a Sec in positions 169 and 302.;
Catalytic Activity3,5,3'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2). {ECO:0000255|PROSITE-ProRule:PRU10107}.
FunctionResponsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
PtmUbiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19651899}.
Sequence CautionSequence=AAC95470.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the iodothyronine deiodinase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
SubunitInteracts with USP20 and USP33. Interacts with MARCH6. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19651899}.
Tissue SpecificityHeart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/DIO2ID44390ch14q31.html";
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