MGP Database

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MGP000871

Ontology/Pathway Information

Entrez Gene ID1812
Gene Namedopamine receptor D1
Gene Symbol DRD1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0005887 IC:BHF-UCLCintegral component of plasma membrane
GO:0005634 IEA:EnsemblCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0035240 IMP:BHF-UCLFdopamine binding
GO:0004952 IDA:MGIFdopamine neurotransmitter receptor activity
GO:0001588 IDA:BHF-UCLFdopamine neurotransmitter receptor activity, coupled via Gs
GO:0007190 IDA:BHF-UCLPactivation of adenylate cyclase activity
GO:0007191 IDA:BHF-UCLPadenylate cyclase-activating dopamine receptor signaling pathway
GO:0007189 IDA:UniProtKBPadenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007628 ISS:BHF-UCLPadult walking behavior
GO:0014002 IEA:EnsemblPastrocyte development
GO:0001662 IEA:EnsemblPbehavioral fear response
GO:0048148 IEA:EnsemblPbehavioral response to cocaine
GO:0071870 IDA:BHF-UCLPcellular response to catecholamine stimulus
GO:0021853 ISS:BHF-UCLPcerebral cortex GABAergic interneuron migration
GO:0001661 IEA:EnsemblPconditioned taste aversion
GO:0021542 IEA:EnsemblPdentate gyrus development
GO:0042417 IC:BHF-UCLPdopamine metabolic process
GO:0015872 IEA:EnsemblPdopamine transport
GO:0046323 IEA:EnsemblPglucose import
GO:0007187 IDA:BHF-UCLPG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007625 IEA:EnsemblPgrooming behavior
GO:0046959 IEA:EnsemblPhabituation
GO:0060292 IEA:EnsemblPlong term synaptic depression
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0042711 IEA:EnsemblPmaternal behavior
GO:0007617 ISS:BHF-UCLPmating behavior
GO:0007613 IEA:EnsemblPmemory
GO:0019228 IEA:EnsemblPneuronal action potential
GO:0035106 IEA:EnsemblPoperant conditioning
GO:0030432 IEA:EnsemblPperistalsis
GO:0060158 IDA:BHF-UCLPphospholipase C-activating dopamine receptor signaling pathway
GO:0010579 IEA:InterProPpositive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0030819 IDA:BHF-UCLPpositive regulation of cAMP biosynthetic process
GO:0030335 ISS:BHF-UCLPpositive regulation of cell migration
GO:0051482 IDA:BHF-UCLPpositive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0043268 ISS:BHF-UCLPpositive regulation of potassium ion transport
GO:0051281 IDA:BHF-UCLPpositive regulation of release of sequestered calcium ion into cytosol
GO:0051968 ISS:BHF-UCLPpositive regulation of synaptic transmission, glutamatergic
GO:0060134 ISS:BHF-UCLPprepulse inhibition
GO:0006606 IEA:EnsemblPprotein import into nucleus
GO:0042053 IEA:EnsemblPregulation of dopamine metabolic process
GO:0051584 IC:BHF-UCLPregulation of dopamine uptake involved in synaptic transmission
GO:0001975 IEA:EnsemblPresponse to amphetamine
GO:0042493 ISS:BHF-UCLPresponse to drug
GO:0046960 IEA:EnsemblPsensitization
GO:0021756 IEA:EnsemblPstriatum development
GO:0007416 ISS:BHF-UCLPsynapse assembly
GO:0001963 IEA:EnsemblPsynaptic transmission, dopaminergic
GO:0001659 IEA:EnsemblPtemperature homeostasis
GO:0019226 ISS:BHF-UCLPtransmission of nerve impulse
GO:0042311 IEA:InterProPvasodilation
GO:0008542 ISS:BHF-UCLPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_16983Amine ligand-binding receptors
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_16968Dopamine receptors
REACT_19327G alpha (s) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00308Dopamine Activation of Neurological Reward System
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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