MGP Database

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MGP000871

UniProt Annotations

Entry Information
Gene Namedopamine receptor D1
Protein EntryDRD1_HUMAN
UniProt IDP21728
SpeciesHuman
Comments
Comment typeDescription
FunctionDopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}.
SubunitInteracts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP. {ECO:0000250}.
Tissue SpecificityDetected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO:0000269|PubMed:2144334}.
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