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MGP000902

UniProt Annotations

Entry Information
Gene Nameenoyl CoA hydratase, short chain, 1, mitochondrial
Protein EntryECHM_HUMAN
UniProt IDP30084
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
FunctionStraight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.
InteractionQ5S007:LRRK2; NbExp=2; IntAct=EBI-719602, EBI-5323863; P40763:STAT3; NbExp=3; IntAct=EBI-719602, EBI-518675; P42227:Stat3 (xeno); NbExp=3; IntAct=EBI-719602, EBI-602878;
PathwayLipid metabolism; fatty acid beta-oxidation.
SimilarityBelongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomohexamer; dimer of trimers. {ECO:0000269|Ref.11}.
Tissue SpecificityLiver, fibroblast, muscle. Barely detectable in spleen and kidney.
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