MGP Database

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MGP000981

Ontology/Pathway Information

Entrez Gene ID2069
Gene Nameepiregulin
Gene Symbol EREG
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005887 TAS:UniProtKBCintegral component of plasma membrane
GO:0005154 ISS:UniProtKBFepidermal growth factor receptor binding
GO:0008083 IBA:GO_CentralFgrowth factor activity
GO:0000187 IBA:GO_CentralPactivation of MAPK activity
GO:0009653 TAS:UniProtKBPanatomical structure morphogenesis
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0007267 IDA:UniProtKBPcell-cell signaling
GO:0019221 IDA:UniProtKBPcytokine-mediated signaling pathway
GO:0007173 ISS:UniProtKBPepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0007143 ISS:UniProtKBPfemale meiotic division
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0030216 TAS:UniProtKBPkeratinocyte differentiation
GO:0043616 IDA:UniProtKBPkeratinocyte proliferation
GO:0042700 ISS:UniProtKBPluteinizing hormone signaling pathway
GO:0009299 IDA:UniProtKBPmRNA transcription
GO:0008285 ISS:UniProtKBPnegative regulation of cell proliferation
GO:0050680 TAS:UniProtKBPnegative regulation of epithelial cell proliferation
GO:0051151 IDA:UniProtKBPnegative regulation of smooth muscle cell differentiation
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001556 ISS:UniProtKBPoocyte maturation
GO:0009887 TAS:UniProtKBPorgan morphogenesis
GO:0001550 ISS:UniProtKBPovarian cumulus expansion
GO:0030728 ISS:UniProtKBPovulation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:0042108 IDA:UniProtKBPpositive regulation of cytokine biosynthetic process
GO:0001819 ISS:UniProtKBPpositive regulation of cytokine production
GO:0045740 IDA:UniProtKBPpositive regulation of DNA replication
GO:0045741 ISS:UniProtKBPpositive regulation of epidermal growth factor-activated receptor activity
GO:0048146 IDA:UniProtKBPpositive regulation of fibroblast proliferation
GO:0045089 ISS:UniProtKBPpositive regulation of innate immune response
GO:0045410 ISS:UniProtKBPpositive regulation of interleukin-6 biosynthetic process
GO:0045840 ISS:UniProtKBPpositive regulation of mitosis
GO:0042327 IDA:UniProtKBPpositive regulation of phosphorylation
GO:0045860 IDA:UniProtKBPpositive regulation of protein kinase activity
GO:0048661 ISS:UniProtKBPpositive regulation of smooth muscle cell proliferation
GO:0048160 ISS:UniProtKBPprimary follicle stage
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0042060 TAS:UniProtKBPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_115854GRB2 events in ERBB2 signaling
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_116022Nuclear signaling by ERBB4
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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