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MGP000981

UniProt Annotations

Entry Information

Gene Name	epiregulin
Protein Entry	EREG_HUMAN
UniProt ID	O14944
Species	Human

Comments

Comment type	Description
Function	Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269\|PubMed:9419975}.
Similarity	Contains 1 EGF-like domain. {ECO:0000255\|PROSITE- ProRule:PRU00076}.
Subcellular Location	Epiregulin: Secreted, extracellular space.
Subcellular Location	Proepiregulin: Cell membrane; Single-pass type I membrane protein.
Subunit	Interacts with EGFR and ERBB4. {ECO:0000269\|PubMed:9419975}.
Tissue Specificity	In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.