MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001005

Ontology/Pathway Information

Entrez Gene ID2149
Gene Namecoagulation factor II (thrombin) receptor
Gene Symbol F2R
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IDA:BHF-UCLCcaveola
GO:0005769 IDA:UniProtKBCearly endosome
GO:0005576 TAS:ReactomeCextracellular region
GO:0005794 TAS:ProtIncCGolgi apparatus
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0031594 ISS:UniProtKBCneuromuscular junction
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0031094 IDA:BHF-UCLCplatelet dense tubular network
GO:0045211 ISS:UniProtKBCpostsynaptic membrane
GO:0001965 ISS:UniProtKBFG-protein alpha-subunit binding
GO:0031681 ISS:UniProtKBFG-protein beta-subunit binding
GO:0004930 ISS:UniProtKBFG-protein coupled receptor activity
GO:0005102 IPI:BHF-UCLFreceptor binding
GO:0015057 IDA:BHF-UCLFthrombin receptor activity
GO:0006919 IDA:BHF-UCLPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000186 ISS:UniProtKBPactivation of MAPKK activity
GO:0009653 TAS:ProtIncPanatomical structure morphogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0002248 IDA:BHF-UCLPconnective tissue replacement involved in inflammatory response wound healing
GO:0007529 ISS:UniProtKBPestablishment of synaptic specificity at neuromuscular junction
GO:0007186 ISS:UniProtKBPG-protein coupled receptor signaling pathway
GO:0048873 ISS:UniProtKBPhomeostasis of number of cells within a tissue
GO:0006954 ISS:UniProtKBPinflammatory response
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0003105 ISS:UniProtKBPnegative regulation of glomerular filtration
GO:0043524 ISS:UniProtKBPnegative regulation of neuron apoptotic process
GO:1900134 ISS:UniProtKBPnegative regulation of renin secretion into blood stream
GO:0007200 IDA:BHF-UCLPphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0030168 IDA:BHF-UCLPplatelet activation
GO:0060155 IC:BHF-UCLPplatelet dense granule organization
GO:0030194 IDA:BHF-UCLPpositive regulation of blood coagulation
GO:0051928 ISS:UniProtKBPpositive regulation of calcium ion transport
GO:0030335 IMP:BHF-UCLPpositive regulation of cell migration
GO:0008284 ISS:UniProtKBPpositive regulation of cell proliferation
GO:0032967 IDA:BHF-UCLPpositive regulation of collagen biosynthetic process
GO:0043280 IDA:BHF-UCLPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007204 ISS:UniProtKBPpositive regulation of cytosolic calcium ion concentration
GO:0051482 ISS:UniProtKBPpositive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0070374 ISS:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0043123 IEP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2000778 IDA:UniProtKBPpositive regulation of interleukin-6 secretion
GO:2000484 IDA:UniProtKBPpositive regulation of interleukin-8 secretion
GO:0046427 IDA:BHF-UCLPpositive regulation of JAK-STAT cascade
GO:0043410 IDA:BHF-UCLPpositive regulation of MAPK cascade
GO:0014068 ISS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0051281 IDA:BHF-UCLPpositive regulation of release of sequestered calcium ion into cytosol
GO:0035025 ISS:UniProtKBPpositive regulation of Rho protein signal transduction
GO:0045987 ISS:UniProtKBPpositive regulation of smooth muscle contraction
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045907 ISS:UniProtKBPpositive regulation of vasoconstriction
GO:0007205 ISS:UniProtKBPprotein kinase C-activating G-protein coupled receptor signaling pathway
GO:0030193 IDA:BHF-UCLPregulation of blood coagulation
GO:0032651 ISS:UniProtKBPregulation of interleukin-1 beta production
GO:0051930 ISS:UniProtKBPregulation of sensory perception of pain
GO:0051209 ISS:UniProtKBPrelease of sequestered calcium ion into cytosol
GO:0032496 ISS:UniProtKBPresponse to lipopolysaccharide
GO:0009611 IDA:BHF-UCLPresponse to wounding
GO:0007262 IDA:BHF-UCLPSTAT protein import into nucleus
GO:0007260 IDA:BHF-UCLPtyrosine phosphorylation of STAT protein
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_1439Common Pathway
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_604Hemostasis
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_798Platelet activation, signaling and aggregation
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
  logo