MGP Database

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MGP001005

UniProt Annotations

Entry Information
Gene Namecoagulation factor II (thrombin) receptor
Protein EntryPAR1_HUMAN
UniProt IDP25116
SpeciesHuman
Comments
Comment typeDescription
DomainThe cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
FunctionHigh affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}.
InteractionQ03135:CAV1; NbExp=3; IntAct=EBI-2803960, EBI-603614; Q9UNN8:PROCR; NbExp=3; IntAct=EBI-2803960, EBI-719705;
PtmA proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
PtmPhosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. {ECO:0000269|PubMed:8955127}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityPlatelets and vascular endothelial cells.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/f2r/";
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