MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001008

Record overview

MGPD IDMGP001008
Gene ID2152
SpeciesHomo sapiens (Human)
Gene Namecoagulation factor III (thromboplastin, tissue factor)
Gene Symbol F3
SynonymsTF; TFA; CD142;
Alternate namestissue factor;
Chromosome1
Map Location1p22-p21
SummaryThis gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for F3

Proteins

tissue factor isoform 1 precursor
Refseq ID:NP_001984
Protein GI:4503641
UniProt ID:P13726
mRNA ID:NM_001993
Length:295
RefSeq Status:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVK
QTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTA
KTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
 
sig_peptide: 1..32
calculated_mol_wt: 3492
peptide sequence: 
METPAWPRVPRPETAVARTLLLGWVFAQVAGA

mat_peptide: 33..238
product: tissue factor isoform 2
calculated_mol_wt: 23671
peptide sequence: 
SGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEF
TPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKYSTSLELWYLWSSSLSSSWLYLYTSVERQEWGRA
GRRTPH

sig_peptide: 1..32
calculated_mol_wt: 3492
peptide sequence: 
METPAWPRVPRPETAVARTLLLGWVFAQVAGA

mat_peptide: 33..295
product: tissue factor isoform 1
calculated_mol_wt: 29594
peptide sequence: 
SGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEF
TPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNR
KSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
 
tissue factor isoform 2 precursor
Refseq ID:NP_001171567
Protein GI:296010912
UniProt ID:P13726
mRNA ID:NM_001178096
Length:238
RefSeq Status:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVK
QTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKYS
TSLELWYLWSSSLSSSWLYLYTSVERQEWGRAGRRTPH
 
sig_peptide: 1..32
calculated_mol_wt: 3492
peptide sequence: 
METPAWPRVPRPETAVARTLLLGWVFAQVAGA

mat_peptide: 33..238
product: tissue factor isoform 2
calculated_mol_wt: 23671
peptide sequence: 
SGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEF
TPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKYSTSLELWYLWSSSLSSSWLYLYTSVERQEWGRA
GRRTPH
 
  logo