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MGP001008

UniProt Annotations

Entry Information
Gene Namecoagulation factor III (thromboplastin, tissue factor)
Protein EntryTF_HUMAN
UniProt IDP13726
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms may exist.; Name=1; Synonyms=flTF; IsoId=P13726-1; Sequence=Displayed; Name=2; Synonyms=asHTF; IsoId=P13726-2; Sequence=VSP_041896, VSP_041897;
FunctionInitiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293}.
InductionTF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. {ECO:0000269|PubMed:19168442}.
InteractionP08709:F7; NbExp=6; IntAct=EBI-1040727, EBI-355972;
SimilarityBelongs to the tissue factor family. {ECO:0000305}.
Subcellular LocationIsoform 1: Membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Secreted.
SubunitInteracts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. {ECO:0000269|PubMed:20634491, ECO:0000269|PubMed:8598903, ECO:0000269|PubMed:9925787}.
Tissue SpecificityLung, placenta and pancreas. {ECO:0000269|PubMed:12652293}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/f3/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF";
Web ResourceName=Wikipedia; Note=Tissue factor entry; URL="http://en.wikipedia.org/wiki/Tissue_factor";
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