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MGP001042

Record overview

MGPD IDMGP001042
Gene ID2205
SpeciesHomo sapiens (Human)
Gene NameFc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Gene Symbol FCER1A
SynonymsFCE1A; FcERI;
Alternate nameshigh affinity immunoglobulin epsilon receptor subunit alpha; Fc IgE receptor, alpha polypeptide; Fc epsilon RI alpha-chain; Fc-epsilon RI-alpha; high affinity immunoglobulin epsilon receptor alpha-subunit; igE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide;
Chromosome1
Map Location1q23
SummaryThe immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for FCER1A

Proteins

high affinity immunoglobulin epsilon receptor subunit alpha precursor
Refseq ID:NP_001992
Protein GI:4503675
UniProt ID:P12319
mRNA ID:NM_002001
Length:257
RefSeq Status:
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNE
SEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPRE
KYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2578
peptide sequence: 
MAPAMESPTLLCVALLFFAPDGVLA

mat_peptide: 26..257
product: high affinity immunoglobulin epsilon receptor subunit alpha
calculated_mol_wt: 27036
peptide sequence: 
VPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEG
QPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFIS
TQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
 
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