MGP Database

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MGP001042

UniProt Annotations

Entry Information
Gene NameFc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Protein EntryFCERA_HUMAN
UniProt IDP12319
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
SimilarityContains 2 Ig-like (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
SubunitTetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
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