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MGP001043

Record overview

MGPD IDMGP001043
Gene ID2206
SpeciesHomo sapiens (Human)
Gene Namemembrane-spanning 4-domains, subfamily A, member 2
Gene Symbol MS4A2
SynonymsAPY; IGEL; IGER; ATOPY; FCERI; IGHER; MS4A1; FCER1B;
Alternate nameshigh affinity immunoglobulin epsilon receptor subunit beta; Fc fragment of IgE, high affinity I, receptor for; beta polypeptide; High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain); high affinity IgE receptor beta subunit; igE Fc receptor subunit beta; immunoglobulin E receptor, high affinity, beta polypeptide;
Chromosome11
Map Location11q12-q13
SummaryThe allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
OrthologsView orthologs and multiple alignments for MS4A2

Proteins

high affinity immunoglobulin epsilon receptor subunit beta isoform 1
Refseq ID:NP_000130
Protein GI:4503677
UniProt ID:Q01362
mRNA ID:NM_000139
Length:244
RefSeq Status:
MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGY
PFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLT
ICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL
 
high affinity immunoglobulin epsilon receptor subunit beta isoform 3
Refseq ID:NP_001243845
Protein GI:379642954
UniProt ID:
mRNA ID:NM_001256916
Length:199
RefSeq Status:
MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGI
TILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL
 
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