MGP Database

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MGP001043

UniProt Annotations

Entry Information
Gene Namemembrane-spanning 4-domains, subfamily A, member 2
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionHigh affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
PolymorphismVariant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia. It seems to be a risk factor for atopic dermatitis and asthma.
PtmPhosphorylated on tyrosine residues by LYN. {ECO:0000250}.
SimilarityBelongs to the MS4A family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitTetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity). {ECO:0000250}.
Tissue SpecificityFound on the surface of mast cells and basophils.
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