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MGP001044

UniProt Annotations

Entry Information
Gene NameFc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Protein EntryFCERG_HUMAN
UniProt IDP30273
SpeciesHuman
Comments
Comment typeDescription
FunctionAssociates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. {ECO:0000269|PubMed:8611682}.
InteractionP43405:SYK; NbExp=2; IntAct=EBI-515289, EBI-78302;
SimilarityBelongs to the CD3Z/FCER1G family. {ECO:0000305}.
SimilarityContains 1 ITAM domain. {ECO:0000255|PROSITE- ProRule:PRU00379}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:8611682}.
SubunitIgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E. {ECO:0000250, ECO:0000269|PubMed:18776906, ECO:0000269|PubMed:8611682}.
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