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MGP001053

Record overview

MGPD IDMGP001053
Gene ID2222
SpeciesHomo sapiens (Human)
Gene Namefarnesyl-diphosphate farnesyltransferase 1
Gene Symbol FDFT1
SynonymsSS; SQS; DGPT; ERG9;
Alternate namessqualene synthase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; squalene synthetase;
Chromosome8
Map Location8p23.1-p22
EC Number2.5.1.21
SummaryThis gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FDFT1

Proteins

squalene synthase isoform 1
Refseq ID:NP_001274671
Protein GI:567757574
UniProt ID:P37268
mRNA ID:NM_001287742
Length:417
RefSeq Status:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNF
HSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGED
TERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQY
LTTLSQVTEDYVQTGEH
 
squalene synthase isoform 1
Refseq ID:NP_004453
Protein GI:67089147
UniProt ID:P37268
mRNA ID:NM_004462
Length:417
RefSeq Status:
Protein sequence is identical to GI:567757574 (mRNA isoform)
 
squalene synthase isoform 1
Refseq ID:NP_001274672
Protein GI:567757576
UniProt ID:P37268
mRNA ID:NM_001287743
Length:417
RefSeq Status:
Protein sequence is identical to GI:567757574 (mRNA isoform)
 
squalene synthase isoform 2
Refseq ID:NP_001274673
Protein GI:567757579
UniProt ID:P37268
mRNA ID:NM_001287744
Length:353
RefSeq Status:
MRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTS
EQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELIT
NALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIIS
TIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
 
squalene synthase isoform 2
Refseq ID:NP_001274678
Protein GI:567757587
UniProt ID:P37268
mRNA ID:NM_001287749
Length:353
RefSeq Status:
Protein sequence is identical to GI:567757579 (mRNA isoform)
 
squalene synthase isoform 2
Refseq ID:NP_001274674
Protein GI:567757581
UniProt ID:P37268
mRNA ID:NM_001287745
Length:353
RefSeq Status:
Protein sequence is identical to GI:567757579 (mRNA isoform)
 
squalene synthase isoform 2
Refseq ID:NP_001274676
Protein GI:567757583
UniProt ID:P37268
mRNA ID:NM_001287747
Length:353
RefSeq Status:
Protein sequence is identical to GI:567757579 (mRNA isoform)
 
squalene synthase isoform 2
Refseq ID:NP_001274677
Protein GI:567757585
UniProt ID:P37268
mRNA ID:NM_001287748
Length:353
RefSeq Status:
Protein sequence is identical to GI:567757579 (mRNA isoform)
 
squalene synthase isoform 3
Refseq ID:NP_001274679
Protein GI:567757589
UniProt ID:P37268
mRNA ID:NM_001287750
Length:476
RefSeq Status:
MAAAACGTKAMALFKRTLVLSPAAAPRGPGAGTAPRGCCLPPAAWPCKDWPRGEGGRLWSRLPQSHSHSHSHSHSHSCSSTSPTAVCVVCPQDSLSSSLK
TCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQT
VIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVK
KLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQY
MEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
 
squalene synthase isoform 4
Refseq ID:NP_001274680
Protein GI:567757591
UniProt ID:P37268
mRNA ID:NM_001287751
Length:332
RefSeq Status:
MTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSR
LFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSV
FNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPI
YLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
 
squalene synthase isoform 5
Refseq ID:NP_001274685
Protein GI:567757597
UniProt ID:P37268
mRNA ID:NM_001287756
Length:250
RefSeq Status:
MPWPPRRVLQPGALPDRGQAEASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNAL
HHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIR
TQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
 
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