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MGP001053

UniProt Annotations

Entry Information
Gene Namefarnesyl-diphosphate farnesyltransferase 1
Protein EntryFDFT_HUMAN
UniProt IDP37268
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P37268-1; Sequence=Displayed; Name=2; IsoId=P37268-2; Sequence=VSP_056283; Note=No experimental confirmation available.; Name=3; IsoId=P37268-3; Sequence=VSP_056282; Note=No experimental confirmation available.; Name=4; IsoId=P37268-4; Sequence=VSP_056517; Note=No experimental confirmation available.; Name=5; IsoId=P37268-5; Sequence=VSP_056518; Note=No experimental confirmation available.;
Catalytic Activity2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
SimilarityBelongs to the phytoene/squalene synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitMonomer. {ECO:0000250}.
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