MGP Database

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MGP001053

Ontology/Pathway Information

Entrez Gene ID2222
Gene Namefarnesyl-diphosphate farnesyltransferase 1
Gene Symbol FDFT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005783 IDA:HPACendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 TAS:ProtIncCintegral component of membrane
GO:0004310 TAS:ReactomeFfarnesyl-diphosphate farnesyltransferase activity
GO:0016491 IEA:UniProtKB-KWFoxidoreductase activity
GO:0051996 IEA:UniProtKB-ECFsqualene synthase activity
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006695 TAS:ReactomePcholesterol biosynthetic process
GO:0008299 IEA:UniProtKB-KWPisoprenoid biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006694 TAS:ProtIncPsteroid biosynthetic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_9405Cholesterol biosynthesis
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_116145PPARA activates gene expression
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMP Pathway Links
SMP IDDescription
SMP00095Alendronate Action Pathway
SMP00131Atorvastatin Action Pathway
SMP00111Cerivastatin Action Pathway
SMP00387CHILD Syndrome
SMP00508Cholesteryl ester storage disease
SMP00388Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
SMP00386Desmosterolosis
SMP00119Fluvastatin Action Pathway
SMP00209Hypercholesterolemia
SMP00509Hyper-IgD syndrome
SMP00079Ibandronate Action Pathway
SMP00099Lovastatin Action Pathway
SMP00319Lysosomal Acid Lipase Deficiency (Wolman Disease)
SMP00510Mevalonic aciduria
SMP00117Pamidronate Action Pathway
SMP00089Pravastatin Action Pathway
SMP00112Risedronate Action Pathway
SMP00092Rosuvastatin Action Pathway
SMP00082Simvastatin Action Pathway
SMP00389Smith-Lemli-Opitz Syndrome (SLOS)
SMP00023Steroid Biosynthesis
SMP00511Wolman disease
SMP00107Zoledronate Action Pathway
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