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MGP001094

Record overview

MGPD IDMGP001094
Gene ID2326
SpeciesHomo sapiens (Human)
Gene Nameflavin containing monooxygenase 1
Gene Symbol FMO1
Alternate namesdimethylaniline monooxygenase [N-oxide-forming] 1; FMO 1; Flavin-containing monooxygenase 1 (fetal liver); dimethylaniline oxidase 1; fetal hepatic flavin-containing monooxygenase 1;
Chromosome1
Map Location1q24.3
EC Number1.14.13.8
SummaryMetabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
OrthologsView orthologs and multiple alignments for FMO1

Proteins

dimethylaniline monooxygenase [N-oxide-forming] 1 isoform a
Refseq ID:NP_001269621
Protein GI:544186123
UniProt ID:Q01740
mRNA ID:NM_001282692
Length:536
RefSeq Status:
MQENMAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYAN
HFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSG
TDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGK
VFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGV
NKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTF
KVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL
 
dimethylaniline monooxygenase [N-oxide-forming] 1 isoform b
Refseq ID:NP_002012
Protein GI:4503755
UniProt ID:Q01740
mRNA ID:NM_002021
Length:532
RefSeq Status:
MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDL
LKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIA
VEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIR
PSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLP
PPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIK
ARVVQESPSPFESFLKVFSFLALLVAIFLIFL
 
dimethylaniline monooxygenase [N-oxide-forming] 1 isoform b
Refseq ID:NP_001269622
Protein GI:544186126
UniProt ID:Q01740
mRNA ID:NM_001282693
Length:532
RefSeq Status:
Protein sequence is identical to GI:4503755 (mRNA isoform)
 
dimethylaniline monooxygenase [N-oxide-forming] 1 isoform c
Refseq ID:NP_001269623
Protein GI:544186128
UniProt ID:Q01740
mRNA ID:NM_001282694
Length:469
RefSeq Status:
MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGI
NAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNW
LNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQK
PTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTV
FFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL
 
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