MGP Database

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MGP001094

Ontology/Pathway Information

Entrez Gene ID2326
Gene Nameflavin containing monooxygenase 1
Gene Symbol FMO1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0050660 IEA:InterProFflavin adenine dinucleotide binding
GO:0004497 IDA:MGIFmonooxygenase activity
GO:0050661 IEA:InterProFNADP binding
GO:0004499 IDA:BHF-UCLFN,N-dimethylaniline monooxygenase activity
GO:0070995 IDA:BHF-UCLPNADPH oxidation
GO:0006082 IDA:BHF-UCLPorganic acid metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0009404 IDA:BHF-UCLPtoxin metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13653FMO oxidises nucleophiles
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13705Phase 1 - Functionalization of compounds
SMP Pathway Links
SMP IDDescription
SMP00471Tamoxifen Action Pathway
SMP00606Tamoxifen Metabolism Pathway
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