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MGP001094

UniProt Annotations

Entry Information
Gene Nameflavin containing monooxygenase 1
Protein EntryFMO1_HUMAN
UniProt IDQ01740
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q01740-1; Sequence=Displayed; Name=2; IsoId=Q01740-2; Sequence=VSP_054543; Note=No experimental confirmation available.;
Catalytic ActivityN,N-dimethylaniline + NADPH + O(2) = N,N- dimethylaniline N-oxide + NADP(+) + H(2)O.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionThis protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
SimilarityBelongs to the FMO family. {ECO:0000305}.
Subcellular LocationMicrosome membrane. Endoplasmic reticulum membrane.
Tissue SpecificityExpressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fmo1/";
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