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MGP001144

Record overview

MGPD IDMGP001144
Gene ID2572
SpeciesHomo sapiens (Human)
Gene Nameglutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Gene Symbol GAD2
SynonymsGAD65;
Alternate namesglutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform;
Chromosome10
Map Location10p11.23
EC Number4.1.1.15
SummaryThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for GAD2

Proteins

glutamate decarboxylase 2
Refseq ID:NP_001127838
Protein GI:197276620
UniProt ID:Q05329
mRNA ID:NM_001134366
Length:585
RefSeq Status:
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPA
CDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTA
NTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGV
PLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQ
HTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
 
glutamate decarboxylase 2
Refseq ID:NP_000809
Protein GI:4503875
UniProt ID:Q05329
mRNA ID:NM_000818
Length:585
RefSeq Status:
Protein sequence is identical to GI:197276620 (mRNA isoform)
 
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