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MGP001144

UniProt Annotations

Entry Information
Gene Nameglutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Protein EntryDCE2_HUMAN
UniProt IDQ05329
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=2.15 mM for glutamate {ECO:0000269|PubMed:8999827};
Catalytic ActivityL-glutamate = 4-aminobutanoate + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:17384644};
FunctionCatalyzes the production of GABA.
PtmPalmitoylated; which is required for presynaptic clustering. {ECO:0000269|PubMed:12356867}.
PtmPhosphorylated; which does not affect kinetic parameters or subcellular location. {ECO:0000269|PubMed:8999827}.
Sequence CautionSequence=CAA49554.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the group II decarboxylase family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
SubunitHomodimer. {ECO:0000269|PubMed:10775108, ECO:0000269|PubMed:17384644}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gad2/";
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