MGP Database

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MGP001177

Ontology/Pathway Information

Entrez Gene ID2644
Gene NameGTP cyclohydrolase I feedback regulator
Gene Symbol GCHFR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0030425 IDA:UniProtKBCdendrite
GO:0042470 IDA:UniProtKBCmelanosome
GO:0031965 IDA:UniProtKBCnuclear membrane
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IEA:EnsemblCprotein complex
GO:0016597 IEA:EnsemblFamino acid binding
GO:0004857 IEA:EnsemblFenzyme inhibitor activity
GO:0009890 IEA:InterProPnegative regulation of biosynthetic process
GO:0043105 IEA:EnsemblPnegative regulation of GTP cyclohydrolase I activity
GO:0042133 TAS:ProtIncPneurotransmitter metabolic process
GO:0006809 TAS:ProtIncPnitric oxide biosynthetic process
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12389eNOS activation and regulation
REACT_111217Metabolism
REACT_12508Metabolism of nitric oxide
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
SMP Pathway Links
SMP IDDescription
SMP00486Dopa-responsive dystonia
SMP00487Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency
SMP00488Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps)
SMP00489Hyperphenylalaninemia due to dhpr-deficiency
SMP00005Pterine Biosynthesis
SMP00490Segawa syndrome
SMP00491Sepiapterin reductase deficiency
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