MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001177

UniProt Annotations

Entry Information
Gene NameGTP cyclohydrolase I feedback regulator
Protein EntryGFRP_HUMAN
UniProt IDP30047
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P30047-1; Sequence=Displayed; Name=2; IsoId=P30047-2; Sequence=VSP_055592; Note=No experimental confirmation available.;
FunctionMediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.
SimilarityBelongs to the GFRP family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:16778797}. Nucleus membrane {ECO:0000269|PubMed:16778797}. Cytoplasm, cytosol {ECO:0000269|PubMed:16778797}.
SubunitHomopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity). Interacts with GCH1. {ECO:0000250, ECO:0000269|PubMed:16696853}.
Tissue SpecificityIn epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). {ECO:0000269|PubMed:16778797}.
  logo