MGP Database

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MGP001197

UniProt Annotations

Entry Information
Gene Namegamma-glutamyltransferase 7
Protein EntryGGT7_HUMAN
UniProt IDQ9UJ14
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=a; IsoId=Q9UJ14-1; Sequence=Displayed; Note=Gene prediction confirmed by EST data.; Name=2; IsoId=Q9UJ14-4; Sequence=VSP_008134, VSP_008138, VSP_008139; Note=No experimental confirmation available.; Name=3; Synonyms=GGTL3B, B; IsoId=Q9UJ14-5; Sequence=VSP_008136, VSP_008137; Name=4; IsoId=Q9UJ14-6; Sequence=VSP_008133, VSP_008140, VSP_008141; Note=No experimental confirmation available.;
Catalytic ActivityA (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Catalytic ActivityGlutathione + H(2)O = L-cysteinylglycine + L- glutamate.
FunctionCleaves glutathione conjugates. {ECO:0000250}.
PathwaySulfur metabolism; glutathione metabolism.
Sequence CautionSequence=BAC03394.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the gamma-glutamyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitHeterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A. {ECO:0000250, ECO:0000269|PubMed:12270127}.
Tissue SpecificityWidely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
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