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MGP001223

Record overview

MGPD IDMGP001223
Gene ID2730
SpeciesHomo sapiens (Human)
Gene Nameglutamate-cysteine ligase, modifier subunit
Gene Symbol GCLM
SynonymsGLCLR;
Alternate namesglutamate--cysteine ligase regulatory subunit; GCS light chain; GSC light chain; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; glutamate--cysteine ligase modifier subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein;
Chromosome1
Map Location1p22.1
SummaryGlutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GCLM

Proteins

glutamate--cysteine ligase regulatory subunit
Refseq ID:NP_002052
Protein GI:4504011
UniProt ID:P48507
mRNA ID:NM_002061
Length:274
RefSeq Status:
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVES
NSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDL
TAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
 
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