MGP Database

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MGP001223

Ontology/Pathway Information

Entrez Gene ID2730
Gene Nameglutamate-cysteine ligase, modifier subunit
Gene Symbol GCLM
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 NAS:UniProtKBCcytosol
GO:0017109 IBA:GO_CentralCglutamate-cysteine ligase complex
GO:0030234 IBA:GO_CentralFenzyme regulator activity
GO:0004357 IEA:EnsemblFglutamate-cysteine ligase activity
GO:0035226 IPI:UniProtKBFglutamate-cysteine ligase catalytic subunit binding
GO:0008637 IEA:EnsemblPapoptotic mitochondrial changes
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0006534 IEA:EnsemblPcysteine metabolic process
GO:0006536 IDA:UniProtKBPglutamate metabolic process
GO:0006750 IDA:UniProtKBPglutathione biosynthetic process
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:2001237 IEA:EnsemblPnegative regulation of extrinsic apoptotic signaling pathway
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0035229 IBA:GO_CentralPpositive regulation of glutamate-cysteine ligase activity
GO:0050880 IMP:UniProtKBPregulation of blood vessel size
GO:0051900 IEA:EnsemblPregulation of mitochondrial depolarization
GO:0042493 IDA:UniProtKBPresponse to drug
GO:0051409 IEA:EnsemblPresponse to nitrosative stress
GO:0006979 IDA:UniProtKBPresponse to oxidative stress
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0000096 TAS:ReactomePsulfur amino acid metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_6960Glutathione synthesis and recycling
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_6959Phase II conjugation
REACT_115639Sulfur amino acid metabolism
SMP Pathway Links
SMP IDDescription
SMP001362-Hydroxyglutric Aciduria (D And L Form)
SMP002434-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
SMP005005-oxoprolinase deficiency
SMP001435-Oxoprolinuria
SMP00499Beta-mercaptolactate-cysteine disulfiduria
SMP00013Cysteine Metabolism
SMP00722Cystinosis, ocular nonnephropathic
SMP00183Gamma-Glutamyltransferase Deficiency
SMP00501Gamma-glutamyl-transpeptidase deficiency
SMP00072Glutamate Metabolism
SMP00015Glutathione Metabolism
SMP00337Glutathione Synthetase Deficiency
SMP00385Homocarnosinosis
SMP00339Hyperinsulinism-Hyperammonemia Syndrome
SMP00567Succinic semialdehyde dehydrogenase deficiency
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