MGP Database

MGP001270

Ontology/Pathway Information

Entrez Gene ID	2805
Gene Name	glutamic-oxaloacetic transaminase 1, soluble
Gene Symbol	GOT1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0043679	IEA:Ensembl	C	axon terminus
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005764	IEA:Ensembl	C	lysosome
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0031406	IEA:Ensembl	F	carboxylic acid binding
GO:0004069	IDA:UniProtKB	F	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0047801	ISS:UniProtKB	F	L-cysteine:2-oxoglutarate aminotransferase activity
GO:0080130	IEA:UniProtKB-EC	F	L-phenylalanine:2-oxoglutarate aminotransferase activity
GO:0004609	IEA:Ensembl	F	phosphatidylserine decarboxylase activity
GO:0030170	IEA:InterPro	F	pyridoxal phosphate binding
GO:0008483	TAS:Reactome	F	transaminase activity
GO:0006103	ISS:UniProtKB	P	2-oxoglutarate metabolic process
GO:0006532	IEA:Ensembl	P	aspartate biosynthetic process
GO:0006533	IDA:UniProtKB	P	aspartate catabolic process
GO:0006531	ISS:UniProtKB	P	aspartate metabolic process
GO:0005975	TAS:Reactome	P	carbohydrate metabolic process
GO:0008652	TAS:Reactome	P	cellular amino acid biosynthetic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0032869	IEP:UniProtKB	P	cellular response to insulin stimulus
GO:0055089	IEA:Ensembl	P	fatty acid homeostasis
GO:0006094	TAS:Reactome	P	gluconeogenesis
GO:0006006	TAS:Reactome	P	glucose metabolic process
GO:0019551	IEA:Ensembl	P	glutamate catabolic process to 2-oxoglutarate
GO:0019550	IEA:Ensembl	P	glutamate catabolic process to aspartate
GO:0006536	ISS:UniProtKB	P	glutamate metabolic process
GO:0006114	ISS:UniProtKB	P	glycerol biosynthetic process
GO:0019509	TAS:Reactome	P	L-methionine biosynthetic process from methylthioadenosine
GO:0006107	IEA:Ensembl	P	oxaloacetate metabolic process
GO:0006595	TAS:Reactome	P	polyamine metabolic process
GO:0051384	IEP:UniProtKB	P	response to glucocorticoid
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0000096	TAS:Reactome	P	sulfur amino acid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_238	Amino acid synthesis and interconversion (transamination)
REACT_116125	Disease
REACT_1520	Gluconeogenesis
REACT_723	Glucose metabolism
REACT_264090	Glycogen storage diseases
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_474	Metabolism of carbohydrates
REACT_14820	Metabolism of polyamines
REACT_75881	Methionine salvage pathway
REACT_264430	Myoclonic epilepsy of Lafora
REACT_115639	Sulfur amino acid metabolism

SMP Pathway Links

SMP ID	Description
SMP00169	Alkaptonuria
SMP00020	Arginine and Proline Metabolism
SMP00362	Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
SMP00499	Beta-mercaptolactate-cysteine disulfiduria
SMP00504	Creatine deficiency, guanidinoacetate methyltransferase deficiency
SMP00013	Cysteine Metabolism
SMP00722	Cystinosis, ocular nonnephropathic
SMP00429	Disulfiram Action Pathway
SMP00498	Dopamine beta-hydroxylase deficiency
SMP00188	Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
SMP00190	Hawkinsinuria
SMP00506	Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
SMP00505	Hyperornithinemia with gyrate atrophy (HOGA)
SMP00361	Hyperprolinemia Type I
SMP00360	Hyperprolinemia Type II
SMP00507	L-arginine:glycine amidinotransferase deficiency
SMP00533	Monoamine oxidase-a deficiency (MAO-A)
SMP00363	Ornithine Aminotransferase Deficiency (OAT Deficiency)
SMP00008	Phenylalanine and Tyrosine Metabolism
SMP00206	Phenylketonuria
SMP00207	Prolidase Deficiency (PD)
SMP00208	Prolinemia Type II
SMP00006	Tyrosine Metabolism
SMP00494	Tyrosinemia, transient, of the newborn
SMP00369	Tyrosinemia Type 2 (or Richner-Hanhart syndrome)
SMP00370	Tyrosinemia Type 3 (TYRO3)
SMP00218	Tyrosinemia Type I