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MGP001303

Record overview

MGPD IDMGP001303
Gene ID2876
SpeciesHomo sapiens (Human)
Gene Nameglutathione peroxidase 1
Gene Symbol GPX1
SynonymsGPXD; GSHPX1;
Alternate namesglutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase;
Chromosome3
Map Location3p21.3
EC Number1.11.1.9
SummaryThis gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GPX1

Proteins

glutathione peroxidase 1 isoform 1
Refseq ID:NP_000572
Protein GI:41406084
UniProt ID:P07203
mRNA ID:NM_000581
Length:203
RefSeq Status:
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVR
PGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGP
SCA
 
glutathione peroxidase 1 isoform 2
Refseq ID:NP_958799
Protein GI:41406082
UniProt ID:P07203
mRNA ID:NM_201397
Length:98
RefSeq Status:
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQVRRAERGGAGADVQ
 
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