MGP Database

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MGP001303

Ontology/Pathway Information

Entrez Gene ID2876
Gene Nameglutathione peroxidase 1
Gene Symbol GPX1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005739 IDA:BHF-UCLCmitochondrion
GO:0005634 IEA:EnsemblCnucleus
GO:0043295 IEA:EnsemblFglutathione binding
GO:0004602 IDA:BHF-UCLFglutathione peroxidase activity
GO:0047066 IEA:EnsemblFphospholipid-hydroperoxide glutathione peroxidase activity
GO:0008430 IEA:EnsemblFselenium binding
GO:0017124 IPI:BHF-UCLFSH3 domain binding
GO:0007568 IEA:EnsemblPaging
GO:0060055 IEA:EnsemblPangiogenesis involved in wound healing
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0043534 IEA:EnsemblPblood vessel endothelial cell migration
GO:0045454 IDA:BHF-UCLPcell redox homeostasis
GO:0034599 NAS:ParkinsonsUK-UCLPcellular response to oxidative stress
GO:0001885 IEA:EnsemblPendothelial cell development
GO:0045444 IEA:EnsemblPfat cell differentiation
GO:0006749 IDA:BHF-UCLPglutathione metabolic process
GO:0060047 IMP:BHF-UCLPheart contraction
GO:0042744 IDA:BHF-UCLPhydrogen peroxide catabolic process
GO:0051702 IEA:EnsemblPinteraction with symbiont
GO:0008631 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0019372 TAS:ReactomePlipoxygenase pathway
GO:0051450 IEA:EnsemblPmyoblast proliferation
GO:0043154 IMP:BHF-UCLPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902042 IMP:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0002862 IEA:EnsemblPnegative regulation of inflammatory response to antigenic stimulus
GO:1902176 IEA:EnsemblPnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0090201 IMP:BHF-UCLPnegative regulation of release of cytochrome c from mitochondria
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:1902905 ISS:ParkinsonsUK-UCLPpositive regulation of fibril organization
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:0018158 IEA:EnsemblPprotein oxidation
GO:0006144 TAS:ReactomePpurine nucleobase metabolic process
GO:0006195 TAS:ReactomePpurine nucleotide catabolic process
GO:0040029 IDA:BHF-UCLPregulation of gene expression, epigenetic
GO:0033599 IMP:BHF-UCLPregulation of mammary gland epithelial cell proliferation
GO:0043523 IEA:EnsemblPregulation of neuron apoptotic process
GO:0061136 IDA:BHF-UCLPregulation of proteasomal protein catabolic process
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0051593 IEA:EnsemblPresponse to folic acid
GO:0010332 IEA:EnsemblPresponse to gamma radiation
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0042542 IMP:BHF-UCLPresponse to hydrogen peroxide
GO:0006982 IEA:EnsemblPresponse to lipid hydroperoxide
GO:0035094 IEA:EnsemblPresponse to nicotine
GO:0010269 IMP:BHF-UCLPresponse to selenium ion
GO:0009609 IEA:EnsemblPresponse to symbiotic bacterium
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0009410 IEA:EnsemblPresponse to xenobiotic stimulus
GO:0007605 IEA:EnsemblPsensory perception of sound
GO:0048741 IEA:EnsemblPskeletal muscle fiber development
GO:0043403 IEA:EnsemblPskeletal muscle tissue regeneration
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0001659 IEA:EnsemblPtemperature homeostasis
GO:0006641 IEA:EnsemblPtriglyceride metabolic process
GO:0009650 IMP:BHF-UCLPUV protection
GO:0042311 IEA:EnsemblPvasodilation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_120956Cellular responses to stress
REACT_264249Detoxification of Reactive Oxygen Species
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_1698Metabolism of nucleotides
REACT_2086Purine catabolism
REACT_522Purine metabolism
REACT_150201Synthesis of 12-eicosatetraenoic acid derivatives
REACT_150422Synthesis of 15-eicosatetraenoic acid derivatives
REACT_150209Synthesis of 5-eicosatetraenoic acids
SMP Pathway Links
SMP IDDescription
SMP005005-oxoprolinase deficiency
SMP001435-Oxoprolinuria
SMP00710Acetaminophen Action Pathway
SMP00083Acetylsalicylic Acid Action Pathway
SMP00692Antipyrine Action Pathway
SMP00693Antrafenine Action Pathway
SMP00075Arachidonic Acid Metabolism
SMP00102Bromfenac Action Pathway
SMP00694Carprofen Action Pathway
SMP00096Celecoxib Action Pathway
SMP00093Diclofenac Action Pathway
SMP00289Diflunisal Action Pathway
SMP00084Etodolac Action Pathway
SMP00695Etoricoxib Action Pathway
SMP00696Fenoprofen Action Pathway
SMP00697Flurbiprofen Action Pathway
SMP00183Gamma-Glutamyltransferase Deficiency
SMP00501Gamma-glutamyl-transpeptidase deficiency
SMP00015Glutathione Metabolism
SMP00337Glutathione Synthetase Deficiency
SMP00086Ibuprofen Action Pathway
SMP00104Indomethacin Action Pathway
SMP00085Ketoprofen Action Pathway
SMP00098Ketorolac Action Pathway
SMP00353Leukotriene C4 Synthesis Deficiency
SMP00700Lornoxicam Action Pathway
SMP00699Lumiracoxib Action Pathway
SMP00698Magnesium salicylate Action Pathway
SMP00109Mefenamic Acid Action Pathway
SMP00106Meloxicam Action Pathway
SMP00114Nabumetone Action Pathway
SMP00120Naproxen Action Pathway
SMP00702Nepafenac Action Pathway
SMP00113Oxaprozin Action Pathway
SMP00701Phenylbutazone Action Pathway
SMP00077Piroxicam Action Pathway
SMP00087Rofecoxib Action Pathway
SMP00708Salicylate-sodium Action Pathway
SMP00709Salicylic Acid Action Pathway
SMP00707Salsalate Action Pathway
SMP00094Sulindac Action Pathway
SMP00101Suprofen Action Pathway
SMP00706Tenoxicam Action Pathway
SMP00705Tiaprofenic Acid Action Pathway
SMP00704Tolmetin Action Pathway
SMP00703Trisalicylate-choline Action Pathway
SMP00116Valdecoxib Action Pathway
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