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MGP001303

UniProt Annotations

Entry Information
Gene Nameglutathione peroxidase 1
Protein EntryGPX1_HUMAN
UniProt IDP07203
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07203-1; Sequence=Displayed; Name=2; IsoId=P07203-2; Sequence=VSP_047369, VSP_047370; Note=Gene prediction based on EST data.;
Catalytic Activity2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
FunctionProtects the hemoglobin in erythrocytes from oxidative breakdown.
PtmDuring periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. {ECO:0000250}.
SimilarityBelongs to the glutathione peroxidase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer. Interacts with MIEN1.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx1/";
Web ResourceName=Wikipedia; Note=Glutathione peroxidase entry; URL="http://en.wikipedia.org/wiki/Glutathione_peroxidase";
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