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MGP001308

Record overview

MGPD IDMGP001308
Gene ID2885
SpeciesHomo sapiens (Human)
Gene Namegrowth factor receptor-bound protein 2
Gene Symbol GRB2
SynonymsASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2;
Alternate namesgrowth factor receptor-bound protein 2; HT027; SH2/SH3 adapter GRB2; abundant SRC homology; epidermal growth factor receptor-binding protein GRB2; growth factor receptor-bound protein 3; protein Ash;
Chromosome17
Map Location17q24-q25
SummaryThe protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GRB2

Proteins

growth factor receptor-bound protein 2 isoform 1
Refseq ID:NP_002077
Protein GI:4504111
UniProt ID:P62993
mRNA ID:NM_002086
Length:217
RefSeq Status:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVK
FGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG
QTGMFPRNYVTPVNRNV
 
growth factor receptor-bound protein 2 isoform 2
Refseq ID:NP_987102
Protein GI:45359859
UniProt ID:P62993
mRNA ID:NM_203506
Length:176
RefSeq Status:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVS
RNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
 
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