MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001308

UniProt Annotations

Entry Information
Gene Namegrowth factor receptor-bound protein 2
Protein EntryGRB2_HUMAN
UniProt IDP62993
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Ash-L; IsoId=P62993-1, P29354-1; Sequence=Displayed; Name=2; Synonyms=GRB3-3; IsoId=P62993-2, P29354-2; Sequence=VSP_001839;
DomainThe SH3 domains mediate interaction with RALGPS1 and SHB.
FunctionAdapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
FunctionIsoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
InteractionSelf; NbExp=5; IntAct=EBI-401755, EBI-401755; O92972:- (xeno); NbExp=2; IntAct=EBI-401755, EBI-710506; P26662:- (xeno); NbExp=3; IntAct=EBI-401755, EBI-9099462; P27958:- (xeno); NbExp=3; IntAct=EBI-401755, EBI-706378; P42684:ABL2; NbExp=2; IntAct=EBI-401755, EBI-1102694; Q13444:ADAM15; NbExp=3; IntAct=EBI-401755, EBI-77818; Q15109:AGER; NbExp=2; IntAct=EBI-401755, EBI-1646426; Q01484:ANK2; NbExp=2; IntAct=EBI-401755, EBI-941975; Q12774:ARHGEF5; NbExp=4; IntAct=EBI-401755, EBI-602199; Q9ULH1:ASAP1; NbExp=7; IntAct=EBI-401755, EBI-346622; O43150:ASAP2; NbExp=3; IntAct=EBI-401755, EBI-310968; P30530:AXL; NbExp=3; IntAct=EBI-401755, EBI-2850927; P11274:BCR; NbExp=8; IntAct=EBI-401755, EBI-712838; Q8WV28:BLNK; NbExp=4; IntAct=EBI-401755, EBI-2623522; O60885:BRD4; NbExp=2; IntAct=EBI-401755, EBI-723869; P22681:CBL; NbExp=8; IntAct=EBI-401755, EBI-518228; Q13191:CBLB; NbExp=5; IntAct=EBI-401755, EBI-744027; Q9Y5K6:CD2AP; NbExp=3; IntAct=EBI-401755, EBI-298152; P98082:DAB2; NbExp=2; IntAct=EBI-401755, EBI-1171238; P98078:Dab2 (xeno); NbExp=4; IntAct=EBI-401755, EBI-1391846; P14868:DARS; NbExp=2; IntAct=EBI-401755, EBI-358730; O14490:DLGAP1; NbExp=3; IntAct=EBI-401755, EBI-1753207; Q9P1A6:DLGAP2; NbExp=2; IntAct=EBI-401755, EBI-1753397; Q9Y2H0:DLGAP4; NbExp=2; IntAct=EBI-401755, EBI-722139; Q05193:DNM1; NbExp=3; IntAct=EBI-401755, EBI-713135; P50570:DNM2; NbExp=4; IntAct=EBI-401755, EBI-346547; Q14185:DOCK1; NbExp=2; IntAct=EBI-401755, EBI-446740; P00533:EGFR; NbExp=32; IntAct=EBI-401755, EBI-297353; P54762:EPHB1; NbExp=2; IntAct=EBI-401755, EBI-80252; P04626:ERBB2; NbExp=4; IntAct=EBI-401755, EBI-641062; P21860:ERBB3; NbExp=3; IntAct=EBI-401755, EBI-720706; Q9UJM3:ERRFI1; NbExp=8; IntAct=EBI-401755, EBI-2941912; O15360:FANCA; NbExp=2; IntAct=EBI-401755, EBI-81570; P21802:FGFR2; NbExp=5; IntAct=EBI-401755, EBI-1028658; P21333:FLNA; NbExp=2; IntAct=EBI-401755, EBI-350432; O75369:FLNB; NbExp=2; IntAct=EBI-401755, EBI-352089; Q14315:FLNC; NbExp=2; IntAct=EBI-401755, EBI-489954; Q13480:GAB1; NbExp=5; IntAct=EBI-401755, EBI-517684; Q9UQC2:GAB2; NbExp=14; IntAct=EBI-401755, EBI-975200; Q9H706:GAREM; NbExp=3; IntAct=EBI-401755, EBI-3440103; P35570:Irs1 (xeno); NbExp=5; IntAct=EBI-401755, EBI-520230; Q07666:KHDRBS1; NbExp=8; IntAct=EBI-401755, EBI-1364; P10721:KIT; NbExp=6; IntAct=EBI-401755, EBI-1379503; P05787:KRT8; NbExp=3; IntAct=EBI-401755, EBI-297852; O43561:LAT; NbExp=12; IntAct=EBI-401755, EBI-1222766; Q13094:LCP2; NbExp=7; IntAct=EBI-401755, EBI-346946; P48357:LEPR; NbExp=3; IntAct=EBI-401755, EBI-518596; Q13163:MAP2K5; NbExp=2; IntAct=EBI-401755, EBI-307294; Q92918:MAP4K1; NbExp=8; IntAct=EBI-401755, EBI-881; Q8IVH8:MAP4K3; NbExp=2; IntAct=EBI-401755, EBI-1758170; Q9Y4K4:MAP4K5; NbExp=4; IntAct=EBI-401755, EBI-1279; Q9H204:MED28; NbExp=3; IntAct=EBI-401755, EBI-514199; P35579:MYH9; NbExp=3; IntAct=EBI-401755, EBI-350338; Q8WX92:NELFB; NbExp=2; IntAct=EBI-401755, EBI-347721; Q13177:PAK2; NbExp=2; IntAct=EBI-401755, EBI-1045887; O00750:PIK3C2B; NbExp=2; IntAct=EBI-401755, EBI-641107; P27986:PIK3R1; NbExp=3; IntAct=EBI-401755, EBI-79464; O00459:PIK3R2; NbExp=4; IntAct=EBI-401755, EBI-346930; P19174:PLCG1; NbExp=2; IntAct=EBI-401755, EBI-79387; O14939:PLD2; NbExp=4; IntAct=EBI-401755, EBI-1053996; Q08209:PPP3CA; NbExp=3; IntAct=EBI-401755, EBI-352922; Q9Y478:PRKAB1; NbExp=2; IntAct=EBI-401755, EBI-719769; P34152:Ptk2 (xeno); NbExp=3; IntAct=EBI-401755, EBI-77070; P18031:PTPN1; NbExp=2; IntAct=EBI-401755, EBI-968788; Q06124:PTPN11; NbExp=6; IntAct=EBI-401755, EBI-297779; P35235:Ptpn11 (xeno); NbExp=7; IntAct=EBI-401755, EBI-397236; Q9Y2R2:PTPN22; NbExp=2; IntAct=EBI-401755, EBI-1211241; Q9H3S7:PTPN23; NbExp=6; IntAct=EBI-401755, EBI-724478; P18433:PTPRA; NbExp=8; IntAct=EBI-401755, EBI-2609645; O14522:PTPRT; NbExp=2; IntAct=EBI-401755, EBI-728180; Q8NFH8-2:REPS2; NbExp=8; IntAct=EBI-401755, EBI-8029141; Q15427:SF3B4; NbExp=2; IntAct=EBI-401755, EBI-348469; Q9UPX8:SHANK2; NbExp=2; IntAct=EBI-401755, EBI-1570571; Q9BYB0:SHANK3; NbExp=2; IntAct=EBI-401755, EBI-1752330; P29353:SHC1; NbExp=22; IntAct=EBI-401755, EBI-78835; P29353-1:SHC1; NbExp=3; IntAct=EBI-401755, EBI-8160716; Q07889:SOS1; NbExp=22; IntAct=EBI-401755, EBI-297487; Q62245:Sos1 (xeno); NbExp=11; IntAct=EBI-401755, EBI-1693; Q07890:SOS2; NbExp=8; IntAct=EBI-401755, EBI-298181; O43597:SPRY2; NbExp=3; IntAct=EBI-401755, EBI-742487; O95630:STAMBP; NbExp=3; IntAct=EBI-401755, EBI-396676; O15056:SYNJ2; NbExp=2; IntAct=EBI-401755, EBI-310513; Q92973:TNPO1; NbExp=2; IntAct=EBI-401755, EBI-286693; O75674:TOM1L1; NbExp=2; IntAct=EBI-401755, EBI-712991; Q9ULW0:TPX2; NbExp=2; IntAct=EBI-401755, EBI-1037322; Q16851:UGP2; NbExp=2; IntAct=EBI-401755, EBI-743729; P15498:VAV1; NbExp=2; IntAct=EBI-401755, EBI-625518; Q9UKW4:VAV3; NbExp=5; IntAct=EBI-401755, EBI-297568; O00401:WASL; NbExp=3; IntAct=EBI-401755, EBI-957615; O43516:WIPF1; NbExp=3; IntAct=EBI-401755, EBI-346356; Q8TF74:WIPF2; NbExp=3; IntAct=EBI-401755, EBI-2850112;
SimilarityBelongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SimilarityContains 2 SH3 domains. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationNucleus {ECO:0000269|PubMed:21179510}. Cytoplasm {ECO:0000269|PubMed:21179510}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250}.
SubunitAssociates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Interacts with phosphorylated TOM1L1 and MET. Interacts with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation. Interacts with NISCH, PTPNS1, REPS2 and the syntrophin SNTA1. Interacts with REPS1 and PIK3C2B via its SH3 domains (By similarity). Interacts with HCV NS5A via its SH3 domains. Interacts with CBL and CBLB. Interacts with AJUBA and CLNK (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2. Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1. Interacts with PTPN11. Interacts with PRNP and THEMIS (By similarity). Interacts with FLT1 (tyrosine phosphorylated) and KDR. Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Interacts with RALGPS1 and with HCST. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with GAPT and PTPRE. Interacts (via SH2 domain) with KIF26A. Interacts (via SH3 2) with GAB2. Interacts with ADAM15. Interacts with THEMIS2. Interacts (via SH2 domain) with AXL and KIT (phosphorylated). Interacts with PTPRJ and BCR. Interacts with FLT4 (tyrosine phosphorylated). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PTPN23. Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL, in which GRB2 promotes RTK recruitment by TNK2. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with ERBB4. Interacts with NTRK1 (phosphorylated upon ligand-binding). Interacts with PTK2/FAK1 (tyrosine phosphorylated). Interacts with PTK2B/PYK2 (tyrosine phosphorylated). Isoform 1 interacts with SCIMP. Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with TESPA1 and DAB2. Interacts (via SH3 domains) with GAREM isoform 1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation. Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts with ASAP3 (phosphorylated form). Interacts with CD28. {ECO:0000250, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:10318918, ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:10942756, ECO:0000269|PubMed:10980613, ECO:0000269|PubMed:11063574, ECO:0000269|PubMed:11433379, ECO:0000269|PubMed:11518702, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:11827484, ECO:0000269|PubMed:11912194, ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:12359715, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:16582911, ECO:0000269|PubMed:18296648, ECO:0000269|PubMed:18559951, ECO:0000269|PubMed:19509291, ECO:0000269|PubMed:19523899, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19914172, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:21930792, ECO:0000269|PubMed:22027826, ECO:0000269|PubMed:22561606, ECO:0000269|PubMed:24098653, ECO:0000269|PubMed:7664271, ECO:0000269|PubMed:8262059, ECO:0000269|PubMed:8388384, ECO:0000269|PubMed:8491186, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8798570, ECO:0000269|PubMed:9062191, ECO:0000269|PubMed:9108392, ECO:0000269|PubMed:9148935, ECO:0000269|PubMed:9178760, ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9422736, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9553137}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GRB2ID386ch17q25.html";
  logo