MGP Database

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MGP001336

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Protein EntryGROA_HUMAN
UniProt IDP09341
SpeciesHuman
Comments
Comment typeDescription
FunctionHas chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. {ECO:0000269|PubMed:10095777}.
PtmN-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. {ECO:0000269|PubMed:10095777}.
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Wikipedia; Note=CXCL1 entry; URL="http://en.wikipedia.org/wiki/CXCL1";
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