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MGP001337

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 2
Protein EntryCXCL2_HUMAN
UniProt IDP19875
SpeciesHuman
Comments
Comment typeDescription
FunctionProduced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. {ECO:0000269|PubMed:10725737}.
InteractionP27487:DPP4; NbExp=2; IntAct=EBI-2114901, EBI-2871277;
PharmaceuticalGRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.
PtmThe N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells. {ECO:0000269|PubMed:10725737}.
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Wikipedia; Note=CXCL2 entry; URL="http://en.wikipedia.org/wiki/CXCL2";
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