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MGP001353

Record overview

MGPD IDMGP001353
Gene ID2946
SpeciesHomo sapiens (Human)
Gene Nameglutathione S-transferase mu 2 (muscle)
Gene Symbol GSTM2
SynonymsGST4; GSTM; GTHMUS; GSTM2-2;
Alternate namesglutathione S-transferase Mu 2; GST class-mu 2; GST, muscle; S-(hydroxyalkyl)glutathione lyase M2; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase M2; glutathione S-aryltransferase M2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-transferase M2 (muscle);
Chromosome1
Map Location1p13.3
EC Number2.5.1.18
SummaryCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GSTM2

Proteins

glutathione S-transferase Mu 2 isoform 1
Refseq ID:NP_000839
Protein GI:4504175
UniProt ID:P28161
mRNA ID:NM_000848
Length:218
RefSeq Status:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDIL
ENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKS
SRFLPRPVFTKMAVWGNK
 
glutathione S-transferase Mu 2 isoform 2
Refseq ID:NP_001135840
Protein GI:215277000
UniProt ID:P28161
mRNA ID:NM_001142368
Length:191
RefSeq Status:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDIL
ENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEHS
 
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